Sunday, 24 September 2017

David WIKLER

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Contact

David.Wikler_AT_ulb.ac.be

ULB - LISA CP165/57
50, Av. F.Roosevelt
1050 Bruxelles
Belgium
tel.:++32.2.650.22.91
fax:++32.2.650.22.98

IBA Particle Therapy
6, Rue Jean Etienne Lenoir
1348 Louvain-La-Neuve
Belgium
tel.:++32.10.475971
fax:++32.10.475810

Teaching


Research Topics

  • Registration, Fusion and Integration of Multimodal Medical Data in Image-Guided Surgery Systems.
  • Clinical Validation and Quality Assurance of Medical Imaging Targeted at Treatment.
  • Medical Information Systems for Interventions Management.


Publications

Papers

N. Sadeghi-Meibodi, N. D'Haene, C. Decaestecker, M. Levivier, T. Metens, C. Maris, D. Wikler, D. Balériaux, I. Salmon, S. Goldman,
Apparent diffusion coefficient and cerebral blood volume in brain gliomas: relation to tumor cell density and tumor microvessel density based on stereotactic biopsies.
American journal of neuroradiology, Vol. 29, 3, pp. 476-482, 2008
Bibtex
Bibtex : info:hdl:2013/51761
Note : Journal Article
Abstract : BACKGROUND AND PURPOSE: MR imaging-based apparent diffusion coefficient (ADC) and regional cerebral blood volume (rCBV) measurements have been related respectively to both cell and microvessel density in brain tumors. However, because of the high degree of heterogeneity in gliomas, a direct correlation between these MR imaging-based measurements and histopathologic features is required. The purpose of this study was to correlate regionally ADC and rCBV values with both cell and microvessel density in gliomas, by using coregistered MR imaging and stereotactic biopsies. MATERIALS AND METHODS: Eighteen patients (9 men, 9 women; age range, 19-78 years) with gliomas underwent diffusion-weighted and dynamic susceptibility contrast-enhanced MR imaging before biopsy. Eighty-one biopsy samples were obtained and categorized as peritumoral, infiltrated tissue, or bulk tumor, with quantification of cell and microvessel density. ADC and rCBV values were measured at biopsy sites and were normalized to contralateral white matter on corresponding maps coregistered with a 3D MR imaging dataset. ADC and rCBV ratios were compared with quantitative histologic features by using the Spearman correlation test. RESULTS: The highest correlations were found within bulk tumor samples between rCBV and cell density (r=0.57, P < .001) and rCBV and microvessel density (r=0.46, P < .01). An inverse correlation was found between ADC and microvessel density within bulk tumor (r=-0.36, P < .05), whereas no significant correlation was found between ADC and cell density. CONCLUSION: rCBV regionally correlates with both cell and microvessel density within gliomas, whereas no regional correlation was found between ADC and cell density.


N. Sadeghi-Meibodi, I. Salmon, C. Decaestecker, M. Levivier, T. Metens, D. Wikler, V. Denolin, S. Rorive, N. Massager, D. Balériaux, S. Goldman,
Stereotactic comparison among cerebral blood volume, methionine uptake, and histopathology in brain glioma.
American journal of neuroradiology, Vol. 28, 3, pp. 455-461, 2007
Bibtex
Bibtex : info:hdl:2013/51732
Note : Comparative Study
Abstract : BACKGROUND AND PURPOSE: Vascularity, metabolism, and histologic grade are related in gliomas but the exact determinants of these relationships are not fully defined. We used image coregistration and stereotactic biopsies to regionally compare cerebral blood volume (CBV) and (11)C-methionine (MET) uptake measurements in brain gliomas and to assess their relationship by histopathologic examination. MATERIALS AND METHODS: Fourteen patients with brain gliomas underwent MR imaging, including dynamic susceptibility contrast-enhanced MR and positron-emission tomography (PET) using MET acquired in identical stereotactic conditions before biopsy. MR-based CBV maps were calculated and both CBV maps and PET images were coregistered to anatomic images. Sixty-five biopsy samples were obtained on trajectories targeted toward high MET uptake area. The following histopathologic features were semiquantified in each sample: mitotic activity, endothelial proliferation, cellular pleomorphism, and tumor necrosis. CBV and MET uptake values were measured in the biopsy area and normalized to contralateral white matter. CBV ratios were compared with MET uptake ratios, and both measurements were compared with histologic features of each sample. RESULTS: CBV ratios ranged from 0.08 to 10.24 (median = 1.73), and MET uptake ratios ranged from 0.30 to 4.91 (median = 1.67). There was a positive correlation between CBV ratios and MET uptake ratios (r = 0.65, P < .001). Both CBV and MET uptake ratios were found to be significantly related to endothelial proliferation and mitotic activity (P < .01). CONCLUSION: Within glial tumors, there is a local relationship between CBV and MET uptake measurements. Both provide indices of focal malignant activity.



Book Sections

2007

Wikler, D., Coussaert, O., Schoovaerts, F., Joly, A., Levivier, M. - The role of computer technology in radiosurgery.
Prog Neurol Surg 20:82-90,2007
Bibtex
Author : Wikler, D., Coussaert, O., Schoovaerts, F., Joly, A., Levivier, M.
Title : The role of computer technology in radiosurgery.
In : Prog Neurol Surg -
Address :
Date : 2007
Abstract

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Journal and Conference Proceedings Papers

2006

2005

Kavec, M., Wikler, D., Phillips, C. L. M., Vigneron, L. M., Levivier, M., Verly, J. G. - Update of diagnostic preoperative images using low-field interventional MRI for navigation in neurosurgery: rigid-body registration
Proceedings of the SPIE - The International Society for Optical Engineering 5744(1):520-528,2005
Bibtex
Author : Kavec, M., Wikler, D., Phillips, C. L. M., Vigneron, L. M., Levivier, M., Verly, J. G.
Title : Update of diagnostic preoperative images using low-field interventional MRI for navigation in neurosurgery: rigid-body registration
In : Proceedings of the SPIE - The International Society for Optical Engineering -
Address :
Date : 2005
Abstract

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Tang, B. N., Sadeghi, N., Branle, F., De Witte, O., Wikler, D., Goldman, S. - Semi-quantification of methionine uptake and flair signal for the evaluation of chemotherapy in low-grade oligodendroglioma
J Neurooncol 71(2):161-8,2005
Bibtex
Author : Tang, B. N., Sadeghi, N., Branle, F., De Witte, O., Wikler, D., Goldman, S.
Title : Semi-quantification of methionine uptake and flair signal for the evaluation of chemotherapy in low-grade oligodendroglioma
In : J Neurooncol -
Address :
Date : 2005
Abstract

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De Witte, O., Makiese, O., Wikler, D., Levivier, M., Vandensteene, A., Pandin, P., Baleriaux, D., Brotchi, J. - [Transsphenoidal approach with low field MRI for pituitary adenoma]
Neurochirurgie 51(6):577-83,2005
Bibtex
Author : De Witte, O., Makiese, O., Wikler, D., Levivier, M., Vandensteene, A., Pandin, P., Baleriaux, D., Brotchi, J.
Title : [Transsphenoidal approach with low field MRI for pituitary adenoma]
In : Neurochirurgie -
Address :
Date : 2005
Abstract

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2004

Levivier, M., Massager, N., Wikler, D., Lorenzoni, J., Ruiz, S., Devriendt, D., David, P., Desmedt, F., Simon, S., Van Houtte, P., Brotchi, J., Goldman, S. - Use of stereotactic PET images in dosimetry planning of radiosurgery for brain tumors: clinical experience and proposed classification
J Nucl Med 45(7):1146-54,2004
Bibtex
Author : Levivier, M., Massager, N., Wikler, D., Lorenzoni, J., Ruiz, S., Devriendt, D., David, P., Desmedt, F., Simon, S., Van Houtte, P., Brotchi, J., Goldman, S.
Title : Use of stereotactic PET images in dosimetry planning of radiosurgery for brain tumors: clinical experience and proposed classification
In : J Nucl Med -
Address :
Date : 2004
Abstract

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Wikler, D., Metens, T., David, P., Levivier, M. - [Imaging for stereotaxic treatment of vestibular schwannomas. Error factors and corrections]
Neurochirurgie 50(2-3 Pt 2):282-8,2004
Bibtex
Author : Wikler, D., Metens, T., David, P., Levivier, M.
Title : [Imaging for stereotaxic treatment of vestibular schwannomas. Error factors and corrections]
In : Neurochirurgie -
Address :
Date : 2004
Abstract

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Regis, J., Levivier, M., Wikler, D., Porcheron, D. - [Dosimetric planning for radiosurgical treatment of vestibular schwannomas]
Neurochirurgie 50(2-3 Pt 2):289-300,2004
Bibtex
Author : Regis, J., Levivier, M., Wikler, D., Porcheron, D.
Title : [Dosimetric planning for radiosurgical treatment of vestibular schwannomas]
In : Neurochirurgie -
Address :
Date : 2004
Abstract

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Pirotte, B., Wikler, D., David, P., Lefranc, F., Brotchi, J., Levivier, M. - Magnetic resonance angiography image guidance for the microsurgical clipping of intracranial aneurysms: a report of two cases
Neurol Res 26(4):429-34,2004
Bibtex
Author : Pirotte, B., Wikler, D., David, P., Lefranc, F., Brotchi, J., Levivier, M.
Title : Magnetic resonance angiography image guidance for the microsurgical clipping of intracranial aneurysms: a report of two cases
In : Neurol Res -
Address :
Date : 2004
Abstract

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2003

Wikler, D., Sadeghi, N., Goldman, S., Massager, N., Putaala, M., Levivier, M - Clinical validation methodology for the use of frameless Positron Emission Tomography in Leksell Gamma Knife Radiosurgery
Radiosurgery, 6th International Stereotactic Radiosurgery Society Meeting, Kyoto 5:247-254,2003
Bibtex
Author : Wikler, D., Sadeghi, N., Goldman, S., Massager, N., Putaala, M., Levivier, M
Title : Clinical validation methodology for the use of frameless Positron Emission Tomography in Leksell Gamma Knife Radiosurgery
In : Radiosurgery, 6th International Stereotactic Radiosurgery Society Meeting, Kyoto -
Address :
Date : 2003

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Levivier, M., Wikler, D., De Witte, O., Van de Steene, A., Baleriaux, D., Brotchi, J. - PoleStar N-10 low-field compact intraoperative magnetic resonance imaging system with mobile radiofrequency shielding
Neurosurgery 53(4):1001-6; discussion 1007,2003
Bibtex
Author : Levivier, M., Wikler, D., De Witte, O., Van de Steene, A., Baleriaux, D., Brotchi, J.
Title : PoleStar N-10 low-field compact intraoperative magnetic resonance imaging system with mobile radiofrequency shielding
In : Neurosurgery -
Address :
Date : 2003
Abstract

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Donckier, V., Van Laethem, J. L., Goldman, S., Van Gansbeke, D., Feron, P., Ickx, B., Wikler, D., Gelin, M. - [F-18] fluorodeoxyglucose positron emission tomography as a tool for early recognition of incomplete tumor destruction after radiofrequency ablation for liver metastases
J Surg Oncol 84(4):215-23,2003
Bibtex
Author : Donckier, V., Van Laethem, J. L., Goldman, S., Van Gansbeke, D., Feron, P., Ickx, B., Wikler, D., Gelin, M.
Title : [F-18] fluorodeoxyglucose positron emission tomography as a tool for early recognition of incomplete tumor destruction after radiofrequency ablation for liver metastases
In : J Surg Oncol -
Address :
Date : 2003
Abstract

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2002

Levivier, M., Wikler, D., Massager, N., David, P., Devriendt, D., Lorenzoni, J., Pirotte, B., Desmedt, F., Simon, S., Jr., Goldman, S., Van Houtte, P., Brotchi, J. - The integration of metabolic imaging in stereotactic procedures including radiosurgery: a review
J Neurosurg 97(5 Suppl):542-50,2002
Bibtex
Author : Levivier, M., Wikler, D., Massager, N., David, P., Devriendt, D., Lorenzoni, J., Pirotte, B., Desmedt, F., Simon, S., Jr., Goldman, S., Van Houtte, P., Brotchi, J.
Title : The integration of metabolic imaging in stereotactic procedures including radiosurgery: a review
In : J Neurosurg -
Address :
Date : 2002
Abstract

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Lipschutz, B., Kolinsky, R., Damhaut, P., Wikler, D., Goldman, S. - Attention-dependent changes of activation and connectivity in dichotic listening
Neuroimage 17(2):643-56,2002
Bibtex
Author : Lipschutz, B., Kolinsky, R., Damhaut, P., Wikler, D., Goldman, S.
Title : Attention-dependent changes of activation and connectivity in dichotic listening
In : Neuroimage -
Address :
Date : 2002
Abstract

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2001

De Witte, O., Goldberg, I., Wikler, D., Rorive, S., Damhaut, P., Monclus, M., Salmon, I., Brotchi, J., Goldman, S. - Positron emission tomography with injection of methionine as a prognostic factor in glioma
J Neurosurg 95(5):746-50.,2001
Bibtex
Author : De Witte, O., Goldberg, I., Wikler, D., Rorive, S., Damhaut, P., Monclus, M., Salmon, I., Brotchi, J., Goldman, S.
Title : Positron emission tomography with injection of methionine as a prognostic factor in glioma
In : J Neurosurg -
Address :
Date : 2001
Abstract

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2000

1999

1998

Van Bogaert, P., Wikler, D., Damhaut, P., Szliwowski, H. B., Goldman, S. - Regional changes in glucose metabolism during brain development from the age of 6 years
Neuroimage 8(1):62-8.,1998
Bibtex
Author : Van Bogaert, P., Wikler, D., Damhaut, P., Szliwowski, H. B., Goldman, S.
Title : Regional changes in glucose metabolism during brain development from the age of 6 years
In : Neuroimage -
Address :
Date : 1998
Abstract

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Van Bogaert, P., Wikler, D., Damhaut, P., Szliwowski, H. B., Goldman, S. - Cerebral glucose metabolism and centrotemporal spikes
Epilepsy Res 29(2):123-7.,1998
Bibtex
Author : Van Bogaert, P., Wikler, D., Damhaut, P., Szliwowski, H. B., Goldman, S.
Title : Cerebral glucose metabolism and centrotemporal spikes
In : Epilepsy Res -
Address :
Date : 1998
Abstract

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1997

Biver, F., Wikler, D., Lotstra, F., Damhaut, P., Goldman, S., Mendlewicz, J. - Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex
Br J Psychiatry 171:444-8.,1997
Bibtex
Author : Biver, F., Wikler, D., Lotstra, F., Damhaut, P., Goldman, S., Mendlewicz, J.
Title : Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex
In : Br J Psychiatry -
Address :
Date : 1997
Abstract

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Conference Abstracts